John is Sirius’ Technical Director, managing the company’s innovations, applications support, analytical service and science collaborations. Recent publications include:
High Throughput Measurement of log D and pKa, in Drug Bioavailability, in Estimation of Solubility, Permeability and Absorption. (H. van de Waterbeemd, H. Lennernäs, P. Artursson, eds.). 2003, pp 21-45, Wiley-VCH,
High Throughput Measurement of pKa values in a Mixed-Buffer Linear pH Gradient System. Analytical Chemistry, 2003, 75(4), 883-892
Application of hydrogen bonding calculations in property based drug design. Drug Discovery Today, 2002, 7(20), 1056-1063
Lipophilicity Profiles: Theory and Measurement, in Pharmacokinetic Optimization in Drug Research - Biological, Physicochemical and Computational Strategies (B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy, eds.), Verlag Helvetica Chimica Acta, 2001 pp. 275-304
Current research efforts are devoted to the prediction of passive permeability, and the problems associated with insolubility.
Sirius is a world leader in the measurement of drug physicochemical properties.