Fluidigm develops and manufactures innovative systems based on its integrated
fluidic circuits for life-science research. Its first offering, the Topaz(tm)
system, uses IFCs for the initial screening of conditions that crystallize
target proteins and, subsequently, for scaling up those conditions to produce
diffraction-quality crystals. IFCs are miniature devices-also called chips-that
contain a dense network of channels and wells and as many as hundreds of
thousands of valves to regulate the fluids involved in bio-chemical reactions.
In addition to chips and chemistries, Fluidigm provides the hardware and
software to automate the experiment setup and the detection and analysis of
reaction products.
Matrix
website
Matrix Technologies, a leader in liquid technology, offers an extensive line of
devices and consumables. The company’s liquid handling instrumentation ranges
from hand-held pipettors to automated workstations. One unique automated
system, is The Hydra II Plus-One, a low volume dispenser well suited for set up
of protein samples for crystallography.
Molecular Dimensions
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Molecular Dimensions supplies innovative protein crystal growth screens
developed within our customers’ laboratories as well as, plates, coverslides.,
and protein expression media including SeMet. Molecular Dimensions sells the
only cooled incubators specifically designed for crystal growth. With ± 0.5°C
accuracy from 0 – 50°C these incubators operate virtually vibration free. Now a
new bench-top model is available to compliment the popular 6.36, 8.83 &
13.77 cubic foot range. At Protein Crystallography in Drug Discovery Molecular
Dimensions will demonstrate mosquito™: the ideal robotic liquid handling tool
for setting up protein crystallization drops in high throughput screening
plates.
NextGen Sciences
websites
NextGen Sciences Ltd introduces the expressionfactory, the first system to fully
automate protein expression.
Drug discovery scientists increasingly require protein samples suitable for
crystallography screening. This has led to an urgent need for new tools to
overcome the problems associated with protein expression. NextGen Sciences has
integrated a unique combination of biology, hardware and software tools, which
allow the entire process of expression vector construction, protein expression
and subsequent purification to be fully automated. The result is a technology
enabling systematic and parallel production of many hundreds of purified
proteins, fragments and domains, without user supervision or intervention.
Oxford Diffraction
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Oxford Diffraction designs and manufactures protein and chemical single
crystal X-ray diffraction equipment. Our superior products include the
revolutionary protein diffractometer ‘Xcalibur PX Ultra’ and the patented
‘Helijet’ open flow helium jet. ‘Xcalibur PX Ultra’ features a four circle
kappa goniometer, the revolutionary ‘Enhance Ultra’ X-ray source; which
provides comparable X-ray intensity to a 5 kW rotating anode fitted with
multi-graded confocal optics from a 2.2 kW sealed tube and the patented 165 mm
large area ‘Onyx’ CCD detector. Xcalibur PX Ultra is extremely compact, has a
low cost of ownership and is virtually maintenance free.